sure, you can run the game at 60fps... if you're willing to jump through hoops
To auto-walk or auto-run, press X on the keyboard.
Most people are aware Caps Lock toggles between run and walk, but it also toggles between a slow sneak and a super slow sneak. I was having some trouble sneaking by a group of mutants until I realized this.
Radiation matters more than ever now as it lowers your maximum HP. This means Rad-X and Rad-Away are a lot more important than in previous games. Short of paying a doctor 40 caps, Rad-Away is, as far as I know, the only way to remove radiation sickness.
Early on, you'll probably need concrete for Sanctuary quests. I wasted several minutes looking for it until I realized you can "scrap" various things in the settlement (including cars, collapsed houses, fences, and mailboxes) by pressing V on the keyboard to go into Workshop Mode. You will see the option at the bottom of the Workshop menu, which is activated by pressing R while facing (highlighting) whatever you wish to scrap.
sit... good boy!
Throwing grenades is way more confusing than it should be for PC players. I understand console players have limited buttons, but assigning it to the same key that performs a melee strike is probably the dumbest thing about Fallout 4's controls. You can reassign the key all you want, but you can't split the functions up between two keys. This means whenever you try to pistol whip someone, it's all to easy to toss a molotov instead, setting your enemy as well as yourself on fire. I have a feeling this will be fixed in a future update, but not soon. Anyway, if you want to melee, don't hold the key down. If you want to throw a grenade, make sure you've equipped the grenade and hold the key down until you hear a click.
The Sort option at the bottom of your Pip-Boy's Inventory menu is your new best friend. To the right of "Sort" you'll see parentheses which shows what you're currently sorting by, such as value, weight, and damage.
When bartering, you can highlight your own inventory or the trader's inventory, then press right or left on the arrow keys to sort by weapons, ammo, junk, etc. Speaking of junk...
In most games you can safely sell or ignore junk. In Fallout 4 it's a lot more important for construction. This makes deciding what to take and what to drop a little more overwhelming, but having a companion carry some of the load makes it a little easier.